[THE LEGAL STATUS OF A PSYCHIATRIC EXPERT DURING A FORENSIC PSYCHIATRIC EXPERTISE].

The purpose of the article is to determine the feasibility and necessity of the mandatory participation of a psychiatrist in the conduct of a forensic psychiatric examination under the legislation of Ukraine and Georgia. The task is to outline the ways of improving the norms of the criminal law of both countries in the legal and medical spheres based on the analysis of the norms of the Criminal Procedure Code of Ukraine and the Criminal Procedure Code of Georgia. It has been established that the constitutional provision of the right to human health (in particular the researched one) in Ukraine and Georgia is contained not only in the codes and medical legislation of both states, but also in a number of international legal acts that have been ratified by their parliaments. The analysis of the relevant norms carried out in the article revealed the imperfection of concepts and terms, methods and methods of implementing the norms that should reflect the specified right. The authors of the article found that the main problem of realizing the human right to full legal and medical protection in the conduct of forensic psychiatric examination, as well as in the exercise of the rights and duties of an expert psychiatrist, is the lack of a clear procedure for the participation of a doctor in the conduct of judicial and investigative actions. Scientific research has established that the Criminal Procedure Code of Ukraine, the Criminal Procedure Code of Georgia and methodological recommendations regarding the participation of a psychiatrist in carrying out procedural measures to collect evidence in the commission of a crime have common features, wording and requirements. The authors of the article revealed that the requirements of international legal norms and a certain specificity of the situation for conducting a forensic psychiatric examination dictate the need to amend the criminal procedural legislation of Ukraine and Georgia. Changes in the legislation of these countries should be aimed at a clearer formulation of the basic concepts and terms of the doctor's participation in the conduct of judicial and investigative actions. These new norms of the law will act as a guarantee for the realization of the right to health, meet the basic international principles and requirements in the field of health care and law.

An agenda for research and action toward diverse and just futures for life on Earth.

Decades of research and policy interventions on biodiversity have insufficiently addressed the dual issues of biodiversity degradation and social justice. New approaches are therefore needed. We devised a research and action agenda that calls for a collective task of revisiting biodiversity toward the goal of sustaining diverse and just futures for life on Earth. Revisiting biodiversity involves critically reflecting on past and present research, policy, and practice concerning biodiversity to inspire creative thinking about the future. The agenda was developed through a 2-year dialogue process that involved close to 300 experts from diverse disciplines and locations. This process was informed by social science insights that show biodiversity research and action is underpinned by choices about how problems are conceptualized. Recognizing knowledge, action, and ethics as inseparable, we synthesized a set of principles that help navigate the task of revisiting biodiversity. The agenda articulates 4 thematic areas for future research. First, researchers need to revisit biodiversity narratives by challenging conceptualizations that exclude diversity and entrench the separation of humans, cultures, economies, and societies from nature. Second, researchers should focus on the relationships between the Anthropocene, biodiversity, and culture by considering humanity and biodiversity as tied together in specific contexts. Third, researchers should focus on nature and economies by better accounting for the interacting structures of economic and financial systems as core drivers of biodiversity loss. Finally, researchers should enable transformative biodiversity research and action by reconfiguring relationships between human and nonhuman communities in and through science, policy, and practice. Revisiting biodiversity necessitates a renewed focus on dialogue among biodiversity communities and beyond that critically reflects on the past to channel research and action toward fostering just and diverse futures for human and nonhuman life on Earth.

Una Agenda para la Investigación y la Acción hacia un Futuro Diverso y Justo para la Vida sobre la Tierra Resumen Las décadas de investigación e intervenciones políticas sobre la biodiversidad han tratado significativamente los temas de la degradación de la biodiversidad y la justicia social. Debido a esto, se requieren nuevas estrategias. Diseñamos una agenda de investigación y acción que llama a la labor colectiva de revisar la biodiversidad hacia el objetivo de sustentar un futuro diverso y justo para la vida sobre la Tierra. Cuando se revisa la biodiversidad, se requiere de una reflexión crítica sobre las investigaciones, políticas y prácticas presentes y pasadas sobre la biodiversidad para inspirar un pensamiento creativo acerca del futuro. Desarrollamos la agenda por medio de un proceso de diálogo de dos años que involucró a casi 300 expertos de diversas disciplinas y localidades. Este proceso estuvo orientado por el conocimiento de las ciencias sociales que muestra cómo la investigación y la acción para la biodiversidad están sostenidas por las opciones de cómo están conceptualizados los problemas. Reconocimos al conocimiento, la acción y la ética como inseparables y sintetizamos un conjunto de principios que ayuda a navegar la labor de revisar la biodiversidad. La agenda articula cuatro áreas temáticas para la investigación en el futuro. Primero, los investigadores necesitan revisar las narrativas de la biodiversidad mediante el cuestionamiento de las conceptualizaciones que excluyen a la diversidad y consolidan la separación entre humanos, culturas, economías y sociedades y la naturaleza. Segundo, los investigadores deberían enfocarse en las relaciones entre el antropoceno, la biodiversidad y la cultura al considerar a la humanidad y la biodiversidad como interconectadas en contextos específicos. Tercero, los investigadores deberían enfocarse en la naturaleza y las economías al tener en mejor cuenta la interacción de las estructuras de los sistemas económico y financiero como conductores nucleares de la pérdida de la biodiversidad. Finalmente, los investigadores deberían permitir la investigación y acción transformadoras de la biodiversidad al reconfigurar las relaciones entre las comunidades humanas y no humanas dentro y a través de la ciencia, la política y la práctica. La revisión de la biodiversidad necesita de un enfoque renovado sobre el diálogo entre las comunidades de la biodiversidad y más allá, que reflexione críticamente sobre el pasado para canalizar a la investigación y acción hacia el fomento del futuro justo y diverso para la vida humana y no humana sobre la Tierra.

[The value of 3-dimensional model in the reconstruction of mandibular segment defect. Observations in a clinical case]. / Valoarea modelului tridimensional in reconstructia pierderilor de substanta segmentare ale mandibulei. Observatii pe marginea unui caz clinic.

The use of autogenous bone graft in the reconstruction of mandibular defects following tumor extirpation is a reliable method for further functional rehabilitation. The exact amount of bone needed for harvesting is usually achieved by estimation of the gap and direct measuring. We present the case of a 51-years old patient referred to our clinic for a recurrent mandibular keratocyst. Besides clinical examination, the diagnosis work-up consisted of ortopantomography and computertomography (CT). Based on CT images, a graphic reconstruction of the mandible was realized and a 3D negative template of the scheduled mandibular defect was printed. The tumor was removed by a segmental resection of the mandible, while a fragment of bone tissue similar to the 3D model was harvested from the iliac crest. This bone fragment replaced the mandible defect and was fixed by means of four plates and titanium screws. No postoperative complications occurred. The pathology result confirmed the diagnosis of keratocyst. In conclusion, this method proved to be useful for precise planning of the shape and size of the graft in addition to exact placement of the graft in an acceptable prosthodontically position for future dental implant rehabilitation.

Manejo químico da ferrugem asiática da soja, baseado em diferentes métodos de monitoramento / Chemical management of the soybean asian rust based on different monitoring methods

O objetivo do trabalho foi determinar o momento ideal da aplicação dos fungicidas de ação preventiva, (Opera + Assist)* e (PrioriXtra + Nimbus)*, baseado na detecção inicial de primeiros esporos associado às condições ambientais, monitoramento climático e monitoramento convencional (após a detecção dos primeiros sintomas), verificando sua eficiência no controle da ferrugem asiática da soja. O trabalho foi desenvolvido na fazenda Escola da Universidade Estadual de Londrina, onde foram instalados coletores de esporos na área para detecção dos primeiros esporos e também se fez anotação das condições climáticas obtidas em estação metereológica. As aplicações foram feitas a 1, 7, 14 e 21 dias após detecção dos primeiros esporos, seguindo o monitoramento climático e monitoramento convencional. Foram avaliadas a porcentagem da área foliar infectada, desfolha e produtividade de grãos. Observou-se uma menor porcentagem de infecção foliar, quando os produtos foram aplicados logo no início da detecção dos primeiros esporos (1, 7 e 14 dias após detecção) e seguindo o monitoramento climático e, apesar do produto (PrioriXtra +Nimbus)* ter apresentado menores porcentagens de infecção foliar e desfolha quando aplicado nos diferentes momentos, observou-se que na produtividade de grãos não houve diferença entre os produtos testados.

The objective of this study was to determine the ideal time for the application of the fungicides of preventive action (Opera + Assist)* and (PrioriXtra + Nimbus)*, based on the initial detection of early spores associated with environmental conditions, climate monitoring and conventional monitoring (after the detection of the first symptoms), verifying their effectiveness in the control of Asian soybean rust. The study was conducted at the Londrina State University Experimental Station, where spore collectors were installed in the area for early detection of spores and the climate conditions were monitored in a climate station. The applications were made at 1, 7, 14 and 21 days after first detection of spores, according to the climate monitoring and conventional monitoring. Evaluations were made of the infected leaf area, defoliation and soybean yield. There was a lower percentage of leaf infection when the products were applied early in the detection of spores (1, 7 and 14 days after detection), and according to the climate monitoring. Moreover, despite that the product (Nimbus + PrioriXtra)* presented lower percentages of infected leaf and defoliation when applied at the different times, it was observed that in the final yield of the crop there was no difference between the products tested.

Danos causados pela infecção de oídio em diferentes estádios fenológicos da soja / Damages caused by infection of powdery mildews in different phenological stages of soybeans

Ainda não há estudos precisos que quantifiquem os prejuízos decorrentes de infecção por oídio e/ou outras doenças foliares, para a maioria das culturas de importância econômica no Brasil. O objetivo foi quantificar as perdas causadas por oídio (Microsphaera diffusa) infectando a cultura da soja em diferentes estádios fenológicos e relacioná-las ao desenvolvimento e produtividade da cultura. O experimento foi desenvolvido em ambiente protegido, e os tratamentos foram testemunha controlada, testemunha sem controle, infecção iniciada em R1 ­ R2, infecção iniciada em R ­ R, infecção iniciada em R ­ R e infecção iniciada em R ­ R. A avaliação foi feita 345.15.25.35.4 semanalmente, considerando a porcentagem da área foliar infectada. Os resultados mostraram que, no tratamento em que houve infecções iniciadas em R1-R2 e R3-R4, a porcentagem de área foliar afetada foi maior (41% e 38%, respectivamente), com consequente menor produtividade (1.186,6 e 1.309,5 kg.ha-1 respectivamente). No tratamento em que a infecção ocorreu em R ­ R, houve 5.35.4 a menor média de área foliar afetada pela doença (24%) e a produtividade teve queda de 26%. Os resultados mostraram que as perdas de produtividade pelo oídio na cultivar Embrapa 48 variaram ao redor de 26 a 50%, e que a recomendação oficial para o início de controle do oídio da soja, quando esta se apresentar entre 40 e 50% de severidade, deve ser questionada e outros trabalhos neste âmbito devem ser desenvolvidos para determinação das perdas ocasionadas por esta doença na cultura.

At present there are no precise studies quantifying the damages caused by powdery mildews and other foliar diseases for the majority of economically important crops in Brazil. The objective of the present study was to quantify the losses caused by powdery mildews (Microsphaera diffusa) in soybeans in different phenological stages, and to correlate them with the development and yield of the crop. The trials was carried out in the greenhouse and the treatments were: controlled check, noncontrolled check, infection initiated at stage R1-R2, infection initiated at stage R3-R4, infection initiated at stage R5.1-R5.2, infection initiated at stage R5.3-R5.4. The evaluation was done weekly considering the percentage of infected leaf area. The results showed that for the infection beginning at stages R1-R2 and R3-R4 the percentage of affected leaf area was higher (41% and 38%), with consequently lower yields (1,200 and 1,240 kg ha-1). When the infection occurred later at stage R5.3-R5.4, a lower affected leaf area (24%) was observed, and the yield decreased 26%. The results showed that the loss of yield by powdery mildew in cultivar Embrapa 48 ranged from around 26 to 50%, and that the official recommendation for the beginning of control of powdery mildew of soybean, where it presents between 40 and 50% of severity, should be questioned, and other work in this area should be undertaken to determine the loss caused by this disease in the crop.

Regulation of apoptosis by type III interferons.

OBJECTIVE: Two types of interferons (IFNs), type I (IFN-alpha/beta) and type III (IFN-lambdas), utilize distinct receptor complexes to induce similar signalling and biological activities, including recently demonstrated for IFN-lambdas antitumour activity. However, ability of type III IFNs to regulate cell population growth remains largely uncharacterized. MATERIALS AND METHODS: Intact and modified human colorectal adenocarcinoma HT29 cells were used to study regulation of apoptosis by IFN-lambdas. RESULTS AND CONCLUSIONS: We report that the IFN-lambdaR1 chain of the type III IFN receptor complex possesses an intrinsic ability to trigger apoptosis in cells. Signalling induced through the intracellular domain of IFN-lambdaR1 resulted in G(1)/G(0) phase cell cycle arrest, phosphatidylserine surfacing and chromosomal DNA fragmentation. Caspase-3, caspase-8 and caspase-9 were activated; however, pancaspase inhibitor Z-VAD-FMK did not prevent apoptosis. In addition, the extent of apoptosis correlated with the level of receptor expression and was associated with prolonged IFN-lambda signalling. We also demonstrated that the ability to trigger apoptosis is a unique intrinsic function of all IFN receptors. However, more robust apoptosis was induced by signalling through type III IFN receptor than through type I or type II (IFN-gamma) receptors, suggesting higher cytotoxic potential of type III IFNs. In addition, we observed that IFN-gamma treatment sensitized HT29 cells to IFN-lambda-mediated apoptosis. These results provide evidence that type III IFNs, alone or in combination with other stimuli, have the potential to induce apoptosis.

[Brown tumors of upper and lower jaws in Recklinghausen neurofibromatosis. A case report]. / Tumori brune ale maxilarului si mandibulei in neurofibromatoza Recklinghausen. Observatii pe marginea unui caz.

We report the case of a 41-year-old patient who presented multiple cafe au lait spots and exophytic tumors of the upper jaw, causing facial asymmetry and masticatory impairment. Physical examination and paraclinical investigations established the diagnosis of NF1 (type 1 neurofibromatosis) associated with brown tumors in jaws and left nasal bone, caused by a primary hyperparathyroidism (Oxyphilic adenoma). The parathyroidectomy determines brown tumors regression and sclerosis with no dependence on their localization.

Parallel computation of simple arithmetic using peptide-antibody interactions.

We propose a theoretical model for representing and manipulating binary numbers using peptide-antibody interactions. In particular, we present models to solve simple binary arithmetical problems like addition and subtraction. As the interactions can take place in parallel we show that the number of steps is independent of the size (bits) of the numbers.

Histopathological and enzymological liver alterations in rat liver in the napthol intoxication.

The study was performed on Wistar adult rats divided in 4 experimental and 2 control groups. In the 4 experimental groups, we used the oral naphtol administration in two doses: 15 mg/kg body-weight and 1.5 mg/kg body-weight. The rats were sacrificed 3 months, respectively 10 months later. Some liver parenchyma dystrophic lesions were noticed. In the subacute test group and using high drug doses the lesions were more severe, especially in the female rats. In the chronic test groups, the lesion area was decreased and in the female rats the liver showed normal histological patterns; in this test groups we also noticed a marked hepatocyte regenerative tendency. Histoenzymatically, a decrease of SDH and ATP-ase activity was recorded. The marked decrease of the hepatocyte glycogen content correspond to an increase of the G-6-P activity.

Building a structured model of a complex pharmacokinetic system with time delays.

This paper presents a description of the procedure for building a structured model of a complex pharmacokinetic system on using its transfer function. The example employed is that of the pharmacokinetic system based on gentamicin plasma concentrations after intravenous and intratracheal administration to guinea pigs, describing the pathway of the drug into the systemic circulation after the extravascular injection mentioned. The structured model selected consisted of a submodel of a proportional linear subsystem, two submodels of simple linear dynamic subsystems with time constants of 0.135 +/- 0.065 hr (95% I.C.) and 0.052 +/- 0.049 hr, and two submodels of parallel subsystems with time delays of 0.25 +/- 0.046 hr and 1.135 +/- 0.288 hr, connected in serial. Two estimates of the mean residence time of the total amount of gentamicin in the system, i.e., 0.347 and 0.335 hr, were obtained, based on the system frequency and structured model, respectively. From the methodological point of view, our paper demonstrates the efficiency of combination of modelling in the frequency and in the time domain, designed to facilitate studies of pharmacokinetic systems.

[The evolution of the incidence of glial brain tumors in Moldova in 1981-1991: the effect of excessive accidental hyper-radioactivity]. / Evolutia incidentei tumorilor gliale cerebrale în Moldova în perioada 1981-1991: influenta hiperradioactivitatii accidentale excesive.

The authors discussed the effects of nuclear accident from Chernobyl (1986) upon the histotypes of cerebral glial tumors, first diagnosed during 1981-1991 at the Department of Pathology, Neurosurgical Hospital, Iasi. It's microscopic diagnosis was determined according to the World Health Organization criterion (1979). The investigations established a tendency to diminish the incidence of astrocytomas and to increase the oligo-astrocytic tumors number, after 1986. Malignant astrocytomas did not presented any modifications with statistical significance during the eleven studied years.

[Clinico-epidemiologic observations on the relation of the prevalence of risk factors and the incidence of essential arterial hypertension at a school collective. I]. / Observatii clinico-epidemiologice asupra relatiei dintre prevalenta unor factori de risc si a incidentei hipertensiunii arteriale esentiale într-o colectivitate scolara. Nota I.

In 466 pupils the blood pressure values and the risk factors for essential hypertension were studied. Numerous environmental risk factors were detected, which, depending on each individuals type of reactivity, can be decisive in inducing increase of blood pressure values and the occurrence of arterial hypertension disease at very young ages.

[Bacteria detected in the duodenal aspirate of patients with biliary tract disorders]. / Consideratii asupra bacteriilor depistate în aspiratul duodenal al pacientilor cu suferinte ale cailor biliare.

In 614 patients with pains in the right hypochondrium the cyto-bacterioscopy and bile culture were performed. In 575 patients bile samples were obtained by sterile catheterization and in 39 patients by biliary tract puncture during surgical intervention. It resulted that for a reliable cyto-bacterioscopic examination and its agreement with bile culture results it is necessary to investigate only the samples with pH greater than or equal to 5 and during the first two hours after their collection. The isolated bacterial species can be considered to be etiologic agents of the biliary infection depending on the following parameters: significant quantitative threshold of minimum 10(5) colony forming units per milliliter, presence of inflammatory reaction and activity of the gastric acid barrier.